Database : HANSEN Search on : ANTIGENOS HLA-DR/GENET [Subject descriptor] References found : 7 [refine] Displaying: 1 .. 7   in format [Detailed]

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Id: 19933 Author: Soebono, Haryanto; Giphart, Marius J; Schreuder, Geziena M. T; Klatser, Paul R; Vries, Rene R. P. de. Title: Associations between HLA-DRB1 alleles and leprosy in an Indonesian population. Source: Int. J. Lepr;65(2):190-196, Jun. 1997. tab. Abstract: To investigate whether the susceptibility to leprosy (type), subclinical infection with Mycobacterium leprae and the antibody response against M. leprae-specific antigens are associated with HLA-DR phenotypes sequence-specific oligonucleotide HLA-DRB1 and DQA1 typing and antibody assays have been performed in 79 leprosy patients (41 TT/BT and 38 LL/BL) and 50 healthy controls from a Javanese population in Yogyakarta, Indonesia. DRB1*02 was associated with LL/BL [odds ratio (OR) 2.54, 95% confidence interval (CI) 0.97-9.78, p = 0.037 and attributable risk (AR) 41.5%] but not with TT/BT leprosy (p > 0.05). HLA-DRB1*12 was negatively associated with leprosy (either LL/BL or TT/BT [OR 0.33-0.35, p < 0.05, prevented fraction (PF) 58.8%-65.3%]. No significant association was found between HLA-DRB1 or DQA1 type, anti-M. leprae antibody level and subclinical infection with M. leprae. These data indicate that in this population susceptibility to lepromatous leprosy is associated with HLA-DRB1*02, while resistance to leprosy is associated with HLA-DRB1*12. These associations are not paralleled with associations of the same HLA types with anti-M. leprae antibody level. Finally, the results of this study also support the notion that infection with M. leprae per se is not associated with HLA-DRB1 or DQA1 alleles. (AU)^ien. Descriptors: Hanseníase Dimorfa/genet Hanseníase Virchowiana/genet Hanseníase Tuberculóide/genet Antígenos HLA-DQ/genet Antígenos HLA-DR/genet Location: BR191.1

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Id: 11730 Author: Chua Intra, Boosbun; Peerapakorn, Somchai; Davey, Nick; Jurcevic, Stipo; Busson, Marc; Vordermeier, H. Martin; Pirayavaraporn, Charoon; Ivanyl, Juraj Title: T-cell recognition of mycobacterial groES peptides in Thai leprosy patients and contacts ..- Source: s.l; s.n; 1998. 7 p. ilus, tab, graf. Descriptors: HANSENIASE HANSENIASE HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE MYCOBACTERIUM MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS SEQUENCIA DE AMINOACIDOS EPITOPOS GENES CLASSE II DO COMPLEXO DE HISTOCOMPATIBILIDADE (MHC) PROTEINA GROES ANTIGENOS HLA-D ANTIGENOS HLA-DQ ANTIGENOS HLA-DR EXPOSIÇAO OCUPACIONAL FRAGMENTOS DE PEPTIDIOS LINFOCITOS T Location: BR191.1; 07323/s

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Id: 11472 Author: Dockrell, Hazel M; Brahmbhatt, Shweta; Robertson, Brian D; Britton, Sven; Fruth, Uli; Gebre, Negussie; Hunegnaw, Mesfin; Hussain, Rabia; Manandhar, Rakesh; Murillo, Luis; Pessolani, Maria Cristina V; Roche, Paul; Salgado, Jorge L; Sampaio, Elizabeth; Shahid, Firdaus; Thole, Jelle E. R; Young, Douglas B Title: A postgenomic approach to identification of mycobacterium leprae-specific peptides as T-cell reagents ..- Source: s.l; s.n; 2000. 10 p. tab, graf. Descriptors: HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS EPITOPOS DE LINFOCITO T EPITOPOS DE LINFOCITO T GENOMA BACTERIANO ANTIGENOS HLA-DR ANTIGENOS HLA-DR TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR PEPTIDIOS PEPTIDIOS ESPECIFICIDADE DE ESPÉCIES LINFOCITOS T Location: BR191.1; 08351/s

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Id: 10281 Author: Uko, G. P; Lu, L. Y; Asuquo, M. A; Fici, D; Mahan, S; Awdeh, Z; Udim, E. R; Ding, W; Umana, U; Adewole, T; Fraser, P. A Title: HLA-DRB1 leprogenic mofits in Nigerian populations groups ..- Source: s.l; s.n; 1999. 7 p. tab. Descriptors: HANSENIASE HANSENIASE ALELOS SITIOS DE LIGAÇAO EPITOPOS ANTIGENOS HLA-DR TESTE DE HISTOCOMPATIBILIDADE NIGÉRIA Location: BR191.1; 07420/s

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Id: 10107 Author: Zerva, Loukia; Cizman, Bojana; Mehra, Navinder K; Alahari, Souresh K; Murali, Ramachandran; Zmijewski, Chester M; Kamoun, Malek; Monos, Dimitri Title: Arginine at positions 13 or 70-71 in pocket 4 of HLA-DRB1 alleles is associated with susceptibility to tuberculoid leprosy ..- Source: s.l; s.n; 1996. 8 p. ilus, tab. Descriptors: ALELOS SEQUENCIA DE AMINOACIDOS ARGININA DISTRIBUIÇAO DE QUI-QUADRADO CRISTALOGRAFIA POR RAIOS X SUSCETIBILIDADE A DOENÇA GENES CLASSE II DO COMPLEXO DE HISTOCOMPATIBILIDADE (MHC) ANTIGENOS HLA-DR ANTIGENOS HLA-DR TESTE DE HISTOCOMPATIBILIDADE HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE SISTEMAS MACROMOLECULARES MODELOS MOLECULARES DADOS DE SEQUENCIA MOLECULAR REAÇAO EM CADEIA POR POLIMERASE CONFORMAÇAO PROTÉICA VALORES DE REFERENCIA FATORES DE RISCO Location: BR191.1; 07048/s

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Id: 10047 Author: Mitra, D. K; Rajalingam, R; Taneja, V; Bhattacharyya, B. C; Mehra, N. K Title: HLA-DR polymorphism modulates the cytokine profile of Mycobacterium leprae HSP-reactive CD4+ T cells ..- Source: s.l; s.n; 1997. 8 p. tab, graf. Descriptors: ADJUVANTES IMUNOLOGICOS PROTEINAS DE BACTÉRIAS LINFOCITOS T CD4-POSITIVOS CHAPERONINAS ANTIGENOS HLA-DR PROTEINAS DO CHOQUE TÉRMICO HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS POLIMORFISMO (GENÉTICA) CÉLULAS TH1 CÉLULAS TH2 Location: BR191.1; 07012/s

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Id: 10024 Author: Joko, Satoru; Numaga, Jiro; Fujino, Yujiro; Islam, S. M. M; Maeda, Hiroo Title: Immunogenetics of episcleritis in leprosy ..- Source: s.l; s.n; 1998. 6 p. tab. Descriptors: HANSENIASE HANSENIASE HANSENIASE IMUNOGENÉTICA ALELOS DNA GENOTIPO ANTIGENOS HLA-DQ ANTIGENOS HLA-DQ ANTIGENOS HLA-DR ANTIGENOS HLA-DR RAZAO DE DIFERENÇA POLIMORFISMO DE FRAGMENTO DE RESTRIÇAO ESCLERITE ESCLERITE Location: BR191.1; 06989/s

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